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Clozapine loaded nanostructured lipid carriers engineered for brain targeting via nose-to-brain delivery: optimization and in vivo pharmacokinetic studies

One of the primary concerns is the degradation of peptides in the digestive system, which can reduce their bioavailability

Under the influence of a leaky epithelial barrier, the immune system is locally activated and inflammation develops, which can be transmitted via immune cells and the cytokines they secrete to other systems and organs